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Endocrine Abstracts

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ea0016p172 | Diabetes and cardiovascular diseases | ECE2008

Changes in the sympathetic and sensory innervation of the tail artery, adrenal gland and male reproductive organs of glucose-intolerant Goto-Kakazaki (GK) rats

Morrison John , Dhanasekaran Subramanian , Howarth Christopher

Twelve-month-old GK rats that showed glucose intolerance were compared with age matched Wistar rats. The concentrations of noradrenaline (NA), adrenaline (ADR) dopamine (DOP), Neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP) were measured in tissue samples. The objective was to assess whether glucose intolerance was associated with changes in the noradrenergic and peptidergic nerves innervating the tail artery (TA), seminal vesicle (SV) and corpus cavernosum (C...
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ea0034p14 | Bone | SFEBES2014

Clinical studies of adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 reveal genotype–phenotype correlations and effectiveness of cinacalcet

Hannan Fadil , Rogers Angela , Howles Sarah , Cranston Treena , McKenna Malachi , Richardson Tristan , Babinsky Valerie , Reed Anita , Thakker Clare , Bockenhauer Detlef , Brown Rosalind , Cook Jacqueline , Darzy Ken , Ehtisham Sarah , Graham Una , Hulse Tony , Hunter Steven , Kumar Dhavendra , McKnight John , Morrison Patrick , Mughal Zulf , Pearce Simon , Scheers Isabelle , Wang Timothy , Whyte Michael , Nesbit M Andrew , Thakker Rajesh

Familial hypocalciuric hypercalcaemia (FHH) comprises three types: FHH1, FHH2, and FHH3, which are due to mutations of the calcium-sensing receptor (CaSR), G-protein α 11 subunit (Gα11), and adaptor protein-2 sigma subunit (AP2σ), respectively. The aims of this study were: to assess for genotype–phenotype correlations among the three reported FHH3-causing AP2σ mutations, which all involve the Arg15 residue, and comprise Arg15Cys, Arg15His, and Arg15Leu...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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